Serostim^® [somatropin (rDNA origin) for injection] is indicated for the treatment of HIV wasting in patients receiving antiretroviral therapy. Serostim^® is a human growth hormone and the only therapy for HIV-wasting FDA-approved to increase weight and lean body mass (LBM), and improve physical endurance.

Serostim^® helps your body build and maintain weight and lean body mass. It also helps support your metabolism, using fat for energy instead of lean body mass. Studies have shown that patients with HIV wasting who were given Serostim^® for 12 weeks significantly increased their weight and lean body mass, improved physical endurance, and reported improvements in their perceptions of their HIV-associated wasting symptoms. These perceptions were reported after 12 weeks at both doses of Serostim^® and included:

• Better appetite and more enjoyment in eating
• Favorable change in appearance
• Improvement in how they feel
• Change in weight has significantly improved health

Increases in weight and lean body mass, and improvements in physical endurance were maintained or improved through 24 weeks of treatment in an open label extension phase.

Bodily pain increased and was attributed to musculoskeletal discomfort and increased tissue turgor observed in approximately 1/3 of patients treated with Serostim^®. These side effects are usually manageable with non-prescription pain medicine. In some cases, your doctor may reduce the dose of Serostim^®. Talk to your doctor to see if Serostim^® is right for you. Let your doctor know if you have a history of cancer, diabetes or glucose intolerance.

For other information about Serostim^®, please refer to the full prescribing information.