Take a Second Look at HIV-associated Wasting

Be Aware of HIV-associated wasting

The impact on patients can be serious.

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The pathophysiology of HIV-associated wasting is multifactorial.3,4,5

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Discover the science behind Serostim

For over 10 years, Serostim® has helped treat patients.

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Serostim® is proven to increase weight and lean body mass and improve physical endurance.2,6

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Supporting your patients

The AXIS Center offers your patients reimbursement support for Serostim®.

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Tracking outcomes can help patients reach treatment goals.

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Access the full prescribing information.


References:

  1. Castaneda C. Muscle wasting and protein metabolism. J Anim Sci. 2002;80(E Suppl. 2):E98-E105.
  2. Serostim® [somatropin (rDNA origin) for injection] Prescribing Information. Rockland, MA: EMD Serono; 2007.
  3. Roubenoff R, Grinspoon S, Skolnik PR, et al. Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men. Am J Physiol Endocrinol Metab. 2002;283:E138-E145.
  4. Dudgeon WD, Phillips KD, Carson JA, et al. Counteracting muscle wasting in HIV-infected individuals. HIV Med. 2006;7:299-310.
  5. Grinspoon S, Corcoran C, Stanley T, et al. Effects of androgen administration on the growth hormone-insulin-like growth factor I axis in men with acquired immunodeficiency syndrome wasting. J Clin Endocrinol Metab. 1998;83:4251-4256.
  6. Moyle GJ, Daar ES, Gertner JM, et al. Growth hormone improves lean body mass, physical performance, and quality of life in subjects with HIV-associated weight loss or wasting on highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2004;35:367-375.
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Important Risk Information and Indication Toggle Button

Important Risk Information

Serostim® is contraindicated in patients with active neoplasia and in those with hypersensitivity to growth hormone.1

Serostim® should not be used in patients in intensive care units due to complications following open-heart surgery or abdominal surgery, multiple accidental trauma, or acute respiratory failure.1

The most common adverse reactions associated with Serostim® use were musculoskeletal discomfort and increased tissue turgor (swelling, particularly of the hands or feet).1

Symptoms were dose-related and generally mild-to-moderate in severity, and often subsided with continued treatment or dose reduction.1

Alternate-day treatment is associated with fewer side effects and resulted in a similar improvement in work output and should be considered in patients at increased risk for adverse events.2

Hyperglycemia may occur in HIV-infected individuals for a variety of reasons and has also been reported in Serostim® clinical trials. Patients with a history of hyperglycemia or other risk factors for glucose intolerance should be monitored closely during Serostim® use. Glucose complications include exacerbation of pre-existing diabetes mellitus, new-onset impaired glucose tolerance, and new-onset type 2 diabetes mellitus.1

Post-marketing cases of new-onset impaired glucose intolerance, new-onset type 2 diabetes mellitus, and exacerbation of pre-existing diabetes mellitus have been reported, some of which were serious and persisted following treatment discontinuation.1

  1. Serostim® [somatropin (rDNA origin) for injection] Prescribing Information. Rockland, MA: EMD Serono; 2007.
  2. Moyle GJ, Daar ES, Gertner JM, et al. Growth hormone improves lean body mass, physical performance, and quality of life in subjects with HIV-associated weight loss or wasting on highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2004;35:367-375.

Indication

Serostim® is indicated for the treatment of HIV patients with wasting or cachexia to increase lean body mass and body weight, and improve physical endurance. Concomitant antiretroviral therapy is necessary.

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