There are two reasons why people with HIV-associated wasting may experience decreased
- Abnormal metabolism: the body changes how it uses carbohydrates,
fats, and proteins that are needed to supply energy for everyday activities
- Change in energy source: instead of drawing energy from fat,
the body begins to draw energy from
A decrease in physical endurance is the most common and distressing symptom associated
with HIV-associated wasting.6 It can be more than just feeling tired.
Patients with decreased physical endurance can experience symptoms like:
Things you can do to help improve physical endurance include talking to your healthcare
- Following a healthy,
balanced diet to help maintain weight and increase energy8
- Getting proper nutrition
by keeping healthy pre-packaged or simple meal options in stock when too tired to
- Incorporating physical
activity into your daily routine9
- Getting the proper amount of sleep and rest
- Treatment options for HIV-associated wasting that can help increase physical
endurance. Use the information and resources on this site to help start the conversation
- Serostim® [somatropin (rDNA origin) for injection] Prescribing
Information. Rockland, MA: EMD Serono; 2007.
- Castaneda C. Muscle wasting and protein metabolism. J Anim Sci. 2002;80(E
- Roubenoff R, Grinspoon S, Skolnik PR, et al. Role of cytokines and testosterone
in regulating lean body mass and resting energy expenditure in HIV-infected men.
Am J Physiol Endocrinol Metab. 2002;283:E138-E145.
- Lutz NW, Yahi N, Fantini J, et al. Perturbations of glucose metabolism associated
with HIV infection in human intestinal epithelial cells: a multinuclear magnetic
resonance spectroscopy study. AIDS. 1997;11:147-155.
- Frost RA, Lang CH, Gelato MC. Transient exposure of human myoblasts to tumor necrosis
factor-α inhibits serum and insulin-like growth factor-I stimulated protein
synthesis. Endocrinology. 1997;138:4153-4159.
- Dudgeon WD, Phillips KD, Carson JA, et al. Counteracting muscle wasting in HIV-infected
individuals. HIV Med. 2006;7:299-310.
- Fatigue. United States Department of Veterans Affairs. Available at: http://www.hiv.va.gov/patient/side-effects-guide/fatigue.asp.
Accessed April 4, 2011.
- Diet and Nutrition. HIVInsite Web site. Available at: http://hivinsite.ucsf.edu/hiv?page=pb-daily-diet.
Accessed April 4, 2011.
- Dudgeon WD, Phillips KD, Bopp CM, et al. Physiological and Psychological Effects
of Exercise Interventions in HIV Disease. Aids Patient Care ST. 2004;(18)2.